tag:blogger.com,1999:blog-7410445500476013619.post9161073209436418898..comments2024-03-27T15:56:33.818-04:00Comments on Type 2 Nutrition: The Nutrition Debate #274: “Should Everyone Take Metformin?”danbrownhttp://www.blogger.com/profile/00119737446791634173noreply@blogger.comBlogger4125tag:blogger.com,1999:blog-7410445500476013619.post-66047795373026904192018-05-19T23:43:16.998-04:002018-05-19T23:43:16.998-04:00This comment has been removed by a blog administrator.MDhttps://www.blogger.com/profile/01617416842480029281noreply@blogger.comtag:blogger.com,1999:blog-7410445500476013619.post-59426566883169759442015-07-06T04:19:14.395-04:002015-07-06T04:19:14.395-04:00This is my first time I visit here. This is really...This is my first time I visit here. This is really awesome post ! please try to publish some more like this one.<br /><br />Thanks<br /><a href="http://www.cardiologyfellowship.net/" rel="nofollow">cardiology fellowship</a>Anonymoushttps://www.blogger.com/profile/05907166550299089747noreply@blogger.comtag:blogger.com,1999:blog-7410445500476013619.post-11308085964320837922014-12-31T08:23:24.095-05:002014-12-31T08:23:24.095-05:00I completely agree with your first point. Doctor’s...I completely agree with your first point. Doctor’s are partly to blame, of course. They think, like Mr. Gruber, that Americans are too stupid to understand the principal mechanism of action of metformin, or at least the one most understood at the moment. <br /><br />My understanding is that the full mechanism and range of action of metformin is not understood. I haven’t studied this recently, but I always say that the main reason I take metformin is to deal with gluconeogenesis from eating too much PROTEIN at dinner. I want to suppress this unwanted glucose production from unused amino acids returned to the liver and stored there for this explicit purpose, as a backup source of glucose production when glycogen stores are low and nearly exhausted. After all, the body does require some glucose for various purposes where cells do not contain ATP.<br /><br />But patients think, as you say, that if they are being medicated for prediabetes or frank T2DM that that medication will suppress serum glucose from ingested CARBOHYDRATES. It does not.<br />Of course, metformin apparently has other lesser and lesser known mechanisms of action, but suppression of gluconeogenesis is the one that needs to be told to patients so that they can understand that difference (between PROTEIN and CARBOHYDRATES), but most patients are low-information consumers of health information. They just want their doctors to be in charge of their healthcare. They are essentially in denial, and continue to be so at their own peril. But doctors also have a responsibility, and I’m not sure they are doing their part.<br /><br />Of course, my blog post was reproting on a epidemiological study that suggested that metformin has a benefit in terms of all cause mortality over a population of non- diabetics not taking it compared to a population that was taking it, which is an interesting finding and suggests yet another mechanism of action that I think does support further research. Of course, I like your idea too that once the mechanism is better understood, we could duplicate it in a way that did not require taking a drug. I am with you on that 100% as well.danbrownhttps://www.blogger.com/profile/00119737446791634173noreply@blogger.comtag:blogger.com,1999:blog-7410445500476013619.post-87309722344854010372014-12-29T12:14:10.168-05:002014-12-29T12:14:10.168-05:00The main problem I have seen with Metformin for T2...The main problem I have seen with Metformin for T2 diabetics is a total lack of education about what it can actually DO. I see people who think it works like insulin - "If I eat 2 cookies, I'll just taken an extra pill today." So they take the medication and still keep on eating high carb crap and...oh my...they just keep getting worse. Guess that calls for more medication, right? I think a better way to go than simply say everyone could benefit from metformin would be to find out why that seems to be, then figure out a way to duplicate the effect without the drug. I found I could no longer take metformin on a strict LCHF diet because the drug exacerbated very bad cramps. Why? Maybe because I wasn't storing glycogen in my liver on that diet, and the metformin compounded the problem? I don't know, and of course the doctor wasn't interested in finding out.Jan Blawathttps://www.blogger.com/profile/06697621979002856884noreply@blogger.com