Sunday, March 18, 2018

Type 2 Nutrition #424: Splenda Endulzante, ideal para toda la familia

You don’t have to be a Spanish student to know that this column concerns the artificial sweetener in the yellow packet. A bunch of them were brought to my table with a cup of coffee after lunch one day last winter in Medellín, Colombia. I didn’t use it, however, because I travel with my own little bottle of pure liquid sucralose, the chemical name for a “non-nutritive sweetener” identified with the commercial product Splenda.
What made this particular packet interesting to me was some information in the small print (in Spanish) that is not shown on otherwise identical packets in the U. S.: the percentages of each of the three ingredients, dextrose, maltodextrin, and sucralose, in order by weight, named on both the U. S. and Colombian products.
Just in case you didn’t know, dextrose and maltodextrin are just chemical names for compounds of the glucose molecule. Dextrose is the naturally occurring D-form of the monosaccharide glucose. Maltodextrin is a polysaccharide. That means it is a compound of between 3 and 17 attached glucose molecules. So, just to be absolutely clear, the two major ingredients of Splenda are both glucose.
But we already knew this. What’s new to me is that the Splenda packets in Colombia actually give the percent by weight of each ingredient: dextrose 95.8%, maltodextrin 3.0% and sucralose 1.2%. Wow, you say. That sucralose stuff must be a pretty powerful sweetener! Well, it is. But I say, wow, Splenda is almost 99%, glucose, the very thing that people who are trying to control their blood sugar should be trying to avoid!
So, now that you know, will you do anything differently? Will you carry a small bottle of liquid sucralose in your purse or pocket? I hope some of you will. I also hope that the others, who won’t, will at least know that you can’t trust anyone, who is invested in selling you something, to tell you the truth. We don’t sell anything on this site except an idea…the idea that good nutrition for type 2 diabetics means avoiding, as much as possible, eating carbohydrates, including glucose. And to do that, you must know where the carbs are.
With this in mind, I wrote a 16-page pamphlet in English, and a folleto en español, that describes, with a 20-part Q & A section, my personal transformation from drug-dependent type 2 diabetic to an almost drug-free type 2, in complete remission (A1c=5.1%). In the course of this transformation I lost 170 pounds and turned around a slew of blood markers including blood pressure, cholesterol, and inflammation. After my HDL-C doubled and my TGL dropped by two-thirds, my doctor took me off the statin drug that I took before I began to eat Very Low Carbohydrate (VLC). Did I mention this Very Low Carb way of eating transformed my health?
I wrote the “folleto en español” with the help of a professor in Bogotá who I also had to educate in this Way of Eating. As in so many countries, public health authorities in Colombia, and the compliant population, have followed the lead of the United States. Our governments have enlisted the population-at-large in a huge, catastrophic, failed public health experiment based solely on epidemiological evidence because, in the words of Senator McGovern, chairman of the 1977 U. S. Senate Select Committee on Nutrition and Human Needs, “Senators don't have the luxury the research scientist does of waiting until every last shred of evidence is in.”
As Jeff Ritterman, MD, says in this truly excellent 2015 Truthout article, “Senator McGovern's comment concerning ‘every last shred of evidence’ was widely off the mark. It was never a question of having supportive, but incomplete, evidence. There simply was no convincing scientific evidence at all in support of the commission's recommendations. There still isn't.” And there was and is lots of evidence to the contrary!
The next column will explore another product, one that is being sold as “balanced nutrition for every day health.” If you’re not careful, you might conclude this too is “ideal for all the family.” That product is “Ensure, Original,” sold as a “meal replacement,” and available in grocery stores everywhere. Caveat emptor!!!

Sunday, March 11, 2018

Type 2 Nutrition #423: Okay, I admit it; I’m not perfect

Earlier this winter I spent 6 weeks in Medellin, Colombia, studying Spanish and eating to my heart’s content. Actually, that’s not an apt expression…eating with abandonment would be more accurate. It was not doing my heart or my type 2 diabetes any good to eat “comida tipica,” but in the spirit of cultural discovery, I ate lots of “arepas” (corn cakes) and, just once, “ron con pasas” (rum raisin) supermarket ice cream. No excuses offered.
The container felt light when I took it from the freezer compartment, so my first thought was that it was loaded with air, like whipped butter. But when I got home I discovered it was really loaded with raisins and tasted quite good. It wasn’t until I had finished the container (naturally) that I looked at the ingredients. The first one listed was whole milk, then sugar of course, then “grasa vegetal,” or vegetable oil! “Incredible!”
Needless to say, I didn’t eat any more supermarket ice cream. Notice: I didn’t say that I didn’t eat any more ice cream. On a few occasions, in a fine dining restaurant, I had dessert with my coffee and once in a while it included ice cream – homemade, I assumed – with a wonderful dense chocolate cake (see photo). The supermarket I patronized also sold Haagen Dazs, but for a king’s ransom…by Colombian standards.
This is the second time that I have travelled to Colombia to study Spanish. Travel and study are things I can do in retirement, and I actually have an undergraduate degree in Spanish, so my studies are somewhat advanced and are made easier by having somewhere in the back of my brain all the irregular verbs conjugated in a dozen or so tenses. The hard part is not reading or writing or even speaking – but understanding the spoken word. I’m afraid it’s going to take more than a few weeks a year to improve that…so more travel and study.
Acquiring or re-acquiring a skill does take a lot of practice, and immersion is a well known way to do it. That’s how I came to eat Very Low Carb. I jumped in head first. The story has been told here many times but bears repeating. My doctor – who had been trying to get me to lose weight the conventional way – eat less on a balanced diet and exercise more – was desperate when he suggested I eat just 20 grams of carbs a day.
For my part I was motivated because, being unable to weigh in on his office scale (which only went to 350 lbs), I had gone to the Fulton Fish Market in NYC for a commercial scale and learned I weighed 375. Meanwhile, my doctor had read Gary Taubes’s seminal piece, “What if It's All Been a Big Fat Lie,” in the NYT and tried the diet himself. He lost 17 pounds in a month, so he suggested that I try it too, to lose weight.
Well, I did. I lost sixty pounds in 9 months, and a few years later, on 30 carb grams a day, I lost a lot more. I then maintained a 170 pound weight loss until years later, fasting 2 or 3 days a week, I increased my total to 186 pounds. All of this without exercise and without hunger. But the really incredible part is that, from the first day, to avoid hypos, my cocktail of oral antidiabetic medication had to be greatly reduced, eliminating one altogether and cutting the other two in half, TWICE. And later I eliminated the sulfonyluria (glyburide) too.
My doctor was just as surprised as I was by this outcome. Not the weight loss, mind you, but the fact that my type 2 diabetes, from the first week, was thrown into remission. I still take Metformin (actually, with my doctor’s approval, I upped it to 750mg twice a day), and my latest A1c was 5.1%. Recently, several doctors that I have mentioned this to have told me that, clinically speaking, I am no longer a type 2 diabetic.
All of these outcomes – weight loss, A1c and blood sugar control, plus big lipid, blood pressure and inflammation improvements – were made possible only by what I don’t eat. But establishment medicine still refuses to accept that type 2 diabetes is a dietary disease and can be effectively treated this way. Maybe your doctor – or you – will have to be desperate to come to a similarly logical conclusion. I was, and my doctor was too, but it shouldn’t be that way. But they don’t burn heretics at the stake anymore; they just fade away…

Thursday, March 8, 2018

Type 2 Nutrition #422: “energy homeostasis at the cellular level”

A Google search for this quote, written on a Post-It, produced no results. Without the quotes, this snippet got 500k hits, many from Google Scholar. So, my search for attribution appeared to be frustrated. But I had also written down the name Raphael Sirtoli, and another Google search produced “”
I opened that hyperlink and discovered a great resource, founded by Sirtoli, aka Raphi Sirt, and Gabor Erdosi. Erdosi has a Master’s in molecular biology and Sirtoli a degree in biochemistry. Together they founded a Facebook page,, aka Lower Insulin.” It’s a rather esoteric site that is “…not really intended for the layperson. However, [it’s] excellent for the more biochemically-versed individuals….”  They say they are “expert problem solvers, with engineering brains” and invite folks to “chat with them.”
I had made the note, “It all comes down to energy homeostasis at the cellular level” because I wanted to write about it. I have written about it before, here, among other places. I have explored it primarily in the context of weight loss. Sixteen years ago, when my doctor suggested I eat Very Low Carb to lose weight, he had only a vague understanding of the mechanism, but that is why he and most people do it. Patients are content to let their doctor treat their pre-diabetes or type 2 diabetes, but doctors usually don’t write a scrip for weight loss.
If you’re not conversant with the physiology, this is it in a nutshell: When you consistently eat Very Low Carb (VLC), and your stored liver glycogen (from carbs) is used up, besides lowering your blood sugar, your blood insulin level also drops. This low blood insulin level signals the liver to switch from using glucose for fuel to using fat. Your liver then breaks down body fat and thus maintains energy homeostasis (at the cellular level) without slowing down your metabolism. This ONLY occurs when you have low blood INSULIN by eating VLC.
Without understanding at first the how and why, I’ve been following this principle for 16 years and have lost almost 200 pounds. I started at 375 and maintain my weight well below 200 today. It didn’t happen all at once or in exactly the same way. As circumstances required over the years (#419), the details “evolved”, starting with eating a lot and just guessing at the carbs as I ate fewer of them. Today I also incorporate full-day fasting.
As a bonus that neither my doctor nor I fully recognized or appreciated, from the get go I have been free of all my diabetes meds except Metformin, and my type 2 diabetes remains in remission. My latest A1c was 5.2%.
Another “essential” benefit of this VLC Way of Eating, besides easy weight loss and dramatic improvement in blood glucose control, is that while your body is in this state of “energy homeostasis,” you don’t eat as much because YOU ARE NOT HUNGRY. Your body is “happy” because it has all the energy it needs for whatever you want to do. You could run a marathon! Go ahead, Google it. Research exercise physiologists like Jeff Volek and others describe how you avoid “hitting the wall” as you do when you “carb load” and then your body runs out of stored liver and muscle glycogen. Everyone has enough fat (fuel) in storage to run a marathon (or 2 or 3!).
I’m just a lay bloke, long since retired from an unrelated profession. I was fat as a teenager and got fatter and fatter as I ate “a balanced diet,” as my government, my doctor (and his dietitian), and the Certified Diabetes Educators (CDEs), and the American Diabetes Association, and the American Heart Association, etc, have been telling us to do for half a century: “Eating fat makes you fat.” “Eat fruits and grains.” “Eat a ‘heart-healthy,’ ‘one-size-fits-all,’ ‘mostly plant-based’ diet,” and “avoid saturated fat, cholesterol and added salt” and “eat vegetable oils instead.” We’ve been unwitting guinea pigs in the largest uncontrolled experiment in history!
And it has all gone horribly wrong. In science, when an experiment goes wrong, i.e. when the outcomes are shown to cause harm, the ethically responsible thing to do is to STOP THE EXPERIMENT. A classic example was the ACCORD trial in 2008. So, why doesn’t government stop this experiment now? Why don’t they correct the Dietary Guidelines? In the absence of that unlikely scenario, it’ll have to be up to you. Youll have to do it!

Sunday, February 25, 2018

Type 2 Nutrition #421: Heart Benefits of Intermittent Fasting

A recent thank-you email from a neighbor and friend included a link to the Cleveland Clinic’s Heart and Vascular News article, “How Fasting Affects Your Heart.” The subtitle is, “A Cardiologist’s Perspective on Pros and Cons of Fasting.” The Cleveland Clinic is “mainstream medicine,” thus way behind the curve on nutrition, especially saturated fat, but the article makes some excellent points about the benefits of Intermittent Fasting.
Quoting from the article: “Cardiologist Haitham Ahmed, MD, sees many advantages in fasting from food for short periods, and given the promising findings in this ‘emerging area’ of research, he expects that more people will want to try it. Though it depends on what you’re hoping to accomplish (it’s not safe for everyone), it’s beneficial to limit your food intake, in general.  He says, ‘By every measure, eating less is better.’”
The first sub-heading in the article, “CAN EATING LESS STRENGTHEN YOUR HEART?” begins, “Research shows that fasting can lower blood pressure, reduce cholesterol, control diabetes and reduce weight. Dr. Ahmed says, ‘Four of the major risk factors for heart disease are high blood pressure and cholesterol, diabetes and weight, so there’s a secondary impact. If we reduce those, we can reduce the risk of heart disease.’”
Well, I’d call that an endorsement of fasting. The Four Horsemen of the Apocalypse managed. Alas, “One word of caution, though,” Dr. Ahmed says. “Fasting can lead to an electrolyte imbalance. This can make the heart unstable and prone to arrhythmias. So whenever we prescribe a protein-sparing modified fast, we do blood tests…and prescribe potassium supplementation to prevent electrolyte imbalance from occurring.’”
Electrolyte balance is a good cautionary note. I take supplemental potassium…and magnesium too. I also add salt to almost everything I eat. And my Electrolyte Panel is always great, with everything in mid-range.
A “protein-sparing modified fast” is a Very Low Carb (VLC), moderate protein diet with just enough dietary fat to allow the body to burn body fat to make up for the calorie deficit. The body has a reduced need for dietary glucose on VLC because to keep the brain happy it makes ketones from the breakdown of dietary and body fat. The body obtains some of the glucose it needs from carbs and some via gluconeogenesis from proteins not needed and stored as amino acids in the liver, thus “sparing” the breakdown of muscle protein for glucose.
The Cleveland Clinic’s Dr. Ahmed continues, “Is fasting a good way to lose weight? Although it offers health benefits – including reduced heart disease and weight loss – it’s not really the best way to lose weight. While fasting helps you drop pounds quickly, it doesn’t help you stay in shape.” What?!!! Okay, then add exercise! “(Fasting) offers health benefits – including reduced heart disease and weight loss,” for goodness sake! Remember, although exercise definitely has cardiovascular and other health benefits, exercise isn’t for weight loss.
The Cleveland Clinic then says, “The only time we really recommend fasting for weight [loss] is if someone needs rapid weight loss, for instance, for surgery.” So, are they saying it’s okay for fat people to otherwise be fat, until it makes surgery riskier and therefore inadvisable for the patient (and the surgeon). Geez….
The rest of the Cleveland Clinic article is garbage, with advice to eat a “healthy diet” of “low-fat yogurt” and high-carb foods like dates, dried fruit, chick peas and peanut butter before and after attempting a fasting diet.
My summation: Cleveland Clinic concludes that fasting is a “healthy diet” for the overweight and obese for the four benefits they acknowledge – that it “can lower blood pressure, reduce cholesterol, control diabetes and reduce weight,” and thus, “reduce the risk of heart disease.” Given that, I would double down; I would say that fasting is THE optimal lifestyle for the ENTIRE population. Watch this 22-minute video of the Diet Doctor’s Andreas Eenfeldt interviewing Dominic D'Agostino. In it, D’Agostino, a leading researcher today in ketogenic metabolism, says he follows a “ketogenic intermittent fasting diet” about 95% of the time. 

Sunday, February 18, 2018

Type 2 Nutrition #420: BMIs for the “elderly”

BMI’s for the “elderly”? Note: “elderly” is in quotes here deliberately. If I sound a little riled, it’s because I am riled. This post will be a rant. But I am NOT going to dissect all the epidemiological studies that give guidance to the medical establishment with respect to the optimal BMI for the elderly (≥65). I will reference them only and instead deal with n = 1, the specific individual, in other words, “me,” and maybe “you” too. Read on!
First of all, we (in the U. S. anyway) know what a ridiculous chart the BMI table is anyway. It was created by the infamous Ancel Keys in 1972 and adopted by the World Health Organization (WHO) in the 80s. Our NIH and CDC bought into it 1998. Now virtually everyone (the “elderly” anyway) is measured for height and weight and assigned a BMI practically every time they visit the doctor. Medicare and now the entire U. S. health care establishment follows the WHO public health guidelines and will sanction your doctor if (s)he doesn’t record these statistics every time you visit. Put simply: Their reimbursement by the government will be reduced!
The BMI chart is ridiculous for many reasons, among them: it only measures your height and weight. You are assigned a BMI on that basis regardless of your gender, age, frame or body composition (muscle vs. fat). That number is then used as “guidance” to tell them whether you are “normal,” “overweight,” or “obese.”
The flaws of such an arbitrary chart are myriad and manifest. So, even though your BMI number is indelibly inscribed in your permanent medical record, your doctor presumably has the discretion to provide you with individualized guidance, albeit that guidance less certainly noted on your medical chart. To provide guidance, epidemiologists have studiously pored over millions of medical records for the “elderly” and have concluded that the elderly shouldn’t be normal weight (as the young should). The elderly SHOULD be overweight!
This is interesting to me because, in my dotage, I have finally found, if not the Fountain of Youth, the secret to losing weight and improving my general and diabetic health through a lifestyle change (the Very Low Carb Way of Eating with full-day fasting). Now, for the first time since I was a teenager, I have a chance to be “normal” weight, or at least be on the cusp (BMI≤25). And now I’m reading that I’m too old to be normal weight!  My goal, having a while back becomenot half the man I once was,” is soon to maintain my weight between 172 (BMI=24.7) and 175 pounds (BMI=25.1), and thus maintain an altogether 200 pound weight loss.
However, lumping me in with all the other “elderly” in these studies, the WHO/NIH/CDC  tell me that my BMI should be no less than 27.5 (192 pounds), smack dab in the middle of the “overweight” range for my height. I just worked damn hard to lose that last 20 pounds, and they’re telling me I should be 20 pounds FATTER! The reason, they say, is that epidemiologically speaking, my risk of death (“all cause mortality”) is much higher in the “normal” (BMI<25) weight range. They say that for me a BMI of 27.5 is “ideal,” epidemiologically speaking.
My take: This epidemiological data only looks at the death statistics of the entire “elderly” population. It does not take into account wellness vs. frailty, smoking status, activity level, or even “advanced” age. It includes everyone at or over the age of 65, including nursing home populations and many elderly who are still living independently, some of whom indubitably are in declining health. And that’s not me! I’m actually thriving!
Most in this population are also not eating a nutritious low-carb diet of real food and healthy saturated and monounsaturated fats. And they are NOT avoiding “wheat, excessive fructose and excessive linoleic acid” (n6s).
To all this I say, damn the epidemiologists and anyone else who relies on this crapola to provide guidance to the healthy “elderly.” I’m 76 and I’m going for a BMI between 24 and 25, to maintain my weight between 172 and 175 pounds. My new wardrobe cost too much to just hang in the closet. And trust me, there’s still plenty of fat on my body to carry me through a long illness and to make a cushion for my fat butt at the ballpark.

Sunday, February 11, 2018

Type 2 Nutrition #419: “Secret Cure” for Type 2 Diabetes

I was diagnosed a type 2 diabetic in 1986. For the first 16 years my diabetes was treated, according to the ADA’s Standards of Medical Practice, as a “progressive” disease. I ate, according to the Dietary Guidelines for Americans, a “balanced” diet and was encouraged to exercise regularly. My doctor monitored my blood sugar and prescribed oral medications in increasing doses. Eventually, I was “maxed out” on two classes of oral meds and had started a third. I knew that when I maxed out on it, I would “graduate” to injecting insulin. 
Then in 2002, in an effort to get me to lose weight, my doctor, largely by accident, discovered effectively a “cure” for my type 2 diabetes as a side benefit of losing weight easily and without hunger. In this post I will recount the stunning discovery of this “secret cure” and how this “treatment” has evolved over the years.
After reading Gary Taubes’s “What If It's All Been a Big Fat Lie,” my doctor suggested I try the diet Taubes described to lose weight. As I was leaving his office, my doctor said, “This might even help your diabetes.” It did. In the 1st week, to avoid hypos, I had to eliminate or decrease all the anti-diabetic meds I was taking. I eliminated one and decreased the other 2 by half, TWICE. The diet described was a Very Low Carb diet, just 20 grams of carbohydrates a day. I followed it strictly for 9 months and lost 60 pounds.
With that diet, I counted carbs. I created an Excel table, wrote down everything I ate, just estimating the carb content. Four years later, over the summer, I regained 12 pounds, so I began a different program. This time I raised my daily carb intake to 30 grams and also counted protein, fat and total calories, again recording everything I ate. In the next year I lost 100 pounds and, a little later, 20+ more. Then, after a while, I stopped counting. It was a lot of work and no longer necessary. By that time I knew what to eat and what NOT to eat.
Over the ensuing years I re-gained and re-lost some, using the same principles I learned in the beginning. That included Macronutrient Ratios for food ingested that were a part of the Very Low Carb eating patterns that I started on. The ratios varied somewhat but they were always “Ketogenic.” I settled on 5% carb, 20% protein and 75% fat, mostly saturated and monounsaturated.  On 1200kcal/day that’s 15g of carbs, 60g of protein and 100g of fat. On such a Very Low Carb, high-fat diet, hunger disappears. You don’t need to eat more because, with a low blood insulin level, your body has access to its own fat for energy balance. Thus, the weight loss. ;-)
A couple of years ago, while struggling to lose some “re-gain,” I gave up breakfast. I wasn’t hungry anyway. It had been 2 eggs/2 strips of bacon, then just 3 eggs, with coffee and heavy cream. I kept the coffee and cream. Later, I also gave up lunch. Eating VLC, I wasn’t hungry then either. Lunch had been a small tin of sardines in EVOO, or kippered herring in brine. But I stalled, even on One Meal a Day. My “diet” needed to evolve again.
About a year ago I began full-day fasting. It was suggested to me on Facebook by Megan Ramos, IDM Program Director at Jason Fung’s practice in Toronto. Originally on alternate days (Tue & Thu), it soon evolved to 2-day and then 3-consecutive day fasts. My fast is not a true water fast. It includes the coffee with cream taken with morning pills and a red wine spritzer (5oz red wine + 8oz seltzer) with evening pills. I lost 60+ pounds, and my A1c dropped from 5.8% to 5.1%. Occasionally I cheated a little (I’m not perfect), but my Metformin handled it.
Most recently I added an after-supper apple cider vinegar “cocktail” to the mix. I got the idea at a Keto Dudes Festival last summer. In my wine glass I add 1 Tb Bragg’s apple cider vinegar, a dash of bitters and a little liquid stevia. I then add ice cubes, swirl the mix and fill the glass with seltzer. My FBG this morning was 87mg/dl, and 16 years after starting Very Low Carb, I have maintained my “non-diabetic” A1c and a 180 pound weight loss.
Make no mistake about it: Type 2 Diabetes IS REVERSIBLE. To be clear though, while it is REVERSED, it is NOT CURED. It is IN REMISSION. But, by the ADA’s Standards of Medical Practice, there is no simple blood test (fasting or A1c), that can detect it. Your doctor, therefore, clinically speaking, will consider you “cured.”

Sunday, February 4, 2018

Type 2 Nutrition #418: “The dose makes the poison”

The surprising popularity of “Triglycerides and Alcohol Consumption,” written obliquely several years ago for the benefit of my brother, gave me pause to contemplate how many others out there were interested in the subject. Unbelievably it was the #4 all-time favorite in the Readership Statistics list of “10 Most Popular” posts. Coincidentally, but in a completely different context, I read in another blog recently that, “The dose makes the poison.” This syzygy, a conjunction reflective of last year’s solar eclipse, thus provided a topic to write about.
Alcohol consumption, perhaps to excess, runs in my family. My father was probably, and my mother possibly, alcoholic. I have a drink almost every day. Some define alcoholism as the habit of drinking alcohol every day.
Since I began a 3-consecutive-day, modified fasting routine about a year ago, drinking a glass of wine has been part of my “fast” day routine. On “My Modified Fasting Plan,” on fasting days I make “supper” one red wine spritzer (5oz of red wine with 8 ounces of club soda), to take my evening pills. On non-fasting days, I double the dose. This “allowance” for alcohol is pleasing to me and, I know, to others who enjoy a drink (or two).
Unless we have company who also enjoy a drink before dinner, at home I don’t drink ethyl alcohol (“spirits”). And these days, as we get older, “company” happens less and less. In a restaurant, which we do about once a week, I usually have a cocktail or two, depending on the bartender. A few make them as strong as I do at home. Most do not, in which case I have two. Just once, at lunch with my editor and her husband in Nashville, I actually ordered three. I swear they were watered down…which is how I get to “the dose makes the poison.”
Paracelus, (1493-1541), a Swiss scientist and son of a doctor, is credited with this adage “intended to indicate a basic principle of toxicology” (Wikipedia).  He is generally credited as the “father of toxicology.” He told doctors to “study nature and develop personal experience through experiment” and thus to “emphasize the value of observation in combination with received wisdom.” This leads in turn to the concept of Hormesis.
More Wikipedia: “Hormesis is any process in an… organism [like you and me] that exhibits a biphasic response to exposure to increasing amounts of a substance or condition.” The “biphasic” conditions are “stimulation” and “inhibition.” Wiki continues, “The hermetic zone [is] generally a favorable biological response to low exposure to toxins and others stressors.” [I generally have a “favorable biological response” to one or even two glasses of wine or a “well-made” drink.[ “A pollution or toxin showing Hormesis thus has the opposite effect in small doses as in large doses.” This effect has been shown with stressors like fasting and exercise.
I wrote about “Calorie Restriction and Longevity” and “Calorie Restrition in Humans” years ago. W/r/t exercise, Wiki states, “Individuals with low levels of physical activity are at risk for high levels of oxidative stress, as are individuals engaged in highly intensive exercise programs; however, individuals engaged in moderately intensive, regular exercise experience lower levels of oxidative stress. High levels of oxidative stress have been linked by some with an increased incidence of a variety of diseases.” (all my emphases).
“Alcohol is believed to be hermetic in preventing heart disease and stroke, although the benefits of light drinking may have been exaggerated,” Wiki avers. But, “in 2012, researchers at UCLA found that tiny amounts… of ethanol doubled the lifespan of Caenorhabditis elegans, a round worm frequently used in biological studies.” At least all of our taxpayer money isn’t being wasted on useless scientific research!!!
 Wiki admits, though, “The biochemical mechanisms by which Hormesis works are not well understood.” And they conclude, “Hormesis remains largely unknown to the public.” But Paracelus has shown me how to manage the “stimulation” part: “study [your] nature and develop personal experience through experiment.” My personal interpretation: At home, be disciplined and adhere strictly to protocol. With guests, cater to their wishes. In a restaurant, choose your bartender carefully, and remember always, “The dose makes the poison.”