The National Institutes of Health researcher, Richard L. Veech, addressing
KETOSIS, said it best (to Gary Taubes):
"Doctors are scared of ketosis. They're
always worried about diabetic ketoacidosis.
But ketosis is a normal physiologic state. I would
argue it is the normal state of man.”
I have been
writing about Ketosis and NUTRITIONAL KETOSIS (before it had its new
moniker) in various posts for about 5 years. More recently, Amy Berger, a
blogger at TuitNutrition.com, put together an excellent 3-part series on the
subject starting here. You need
go no further than Amy’s series for all you need to know about the similarities
and differences between “very low carb” and “keto-adapted.” It’s an excellent
source for those who want to lose weight, including
those with Metabolic Syndrome, Pre-Diabetes and Type 2 Diabetes.
The therapeutic KETOGENIC DIET has been around since 1921 when Russell
Wilder developed it for the treatment of childhood epilepsy. He also developed
the formula for the ketogenic/glucogenic ratio (K:G). The keto fraction in the original
ratio is about 90% fat, with adequate protein and de minimis carbohydrates.
Both
Nutritional Ketosis and the therapeutic Ketogenic Diet are dietary regimens
with specific targets; the first is broad and the second narrow but starting to
explode. The broad goal of Nutritional Ketosis is primarily 1) easy weight loss
without hunger, 2) improved control of glucose metabolism for treatment of
metabolic disorders like Pre-Diabetes and Type 2 Diabetes, and 3) huge improvements
in lipid (cholesterol) and inflammation markers.
The narrow
goal of the therapeutic Ketogenic Diet was (and is) the treatment of
drug-resistant epilepsy. Today, however, there is a burgeoning interest in
researching the KETOGENIC DIET as an adjunctive therapy for many other
serious medical conditions including Alzheimer’s disease, Parkinson’s disease,
Huntington’s disease, multiple sclerosis, ALS (Lou Gehrig’s disease), and
various types of cancer.
Years ago I heard Eugene Fine lecture on the alternative use
of ketones as “brain food” in the treatment of brain cancer, specifically
glioblastomas. Brain cancers “feed” on glucose, but while fatty acids (catabolized
from triglycerides) can’t cross the blood-brain barrier, ketones, a byproduct
of the breakdown, can.
While
interesting to me at the time, glioblastomas comprise only about 15% of all
brain tumors and brain tumors only about 2% of all cancers. Recently, however,
I attended the 1st Annual Nutritional Ketosis and Metabolic
Therapeutics Conference in Tampa, FL, and I gained a totally new perspective on
ketones. In this 4-part I will share my lay perspectives from this 3-day event with you. Spoiler
alert: It has transformed my thinking. I’ve had an awakening.
But today I
will just describe what I saw as the component constituencies and then give you
my main takeaway. Remember, this is from the perspective of an old, type 2 diabetic;
as such, what I shared in common with most people over 50 (before changing my
Way of Eating), is a diet-related, genetic expression of a metabolic disorder,
and related body-weight issues (obesity), high blood pressure (hypertension)
and “high” (they say) cholesterol (dyslipidemia). All these things,
epidemiologically speaking, put me at much greater risk of a passel of diseases.
The
conference was organized by PhDs at the University of South Florida and was
attended by many iconic PhDs and MDs in the field. Subject matter was diverse
and included plenary and break-out sessions to accommodate the different
constituencies. The two main themes in the break-out sessions were, as the name
implies, 1) nutritional ketosis and SUPPLEMENTAL KETONES for performance
athletes, and 2) metabolic therapies, also with SUPPLEMENTAL KETONES,
for diseases including brain cancer and Alzheimer’s Disease (AD), both for the
same reason: Ketone bodies are the preferred “brain food” and easily cross the
blood—brain barrier.
In the following columns I will not
explore supplemental ketones from the performance athlete’s perspective. I
will, however, tell you how I have become newly motivated 1) to not just be very low carb/keto-adapted in my
diet (but not particularly interested
in how my urine scores on a keto strip – I never was), and also 2) to introduce ketones to my body every day for
the rest of my life as a therapeutic and perhaps prophylactic
practice.
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