Sunday, April 24, 2016

The Nutrition Debate #325: Supplemental Ketones, a Prophylactic Strategy

In the introduction to this series (#322 here), I say, “I have become newly motivated…to introduce ketones to my body every day…as a prophylactic and perhaps therapeutic practice.” And that after I said I was motivated to continue “…to be very low carb/keto-adapted in my dietary practices.” For the new reader, I have been a Type 2 Diabetic for 30 years and an advocate of Very Low Carb eating for almost 14. With this WOE (Way of Eating), I have achieved 1) weight loss (170 lbs.), without hunger, 2) infinitely better blood sugar control, and 3) blockbuster improvements in blood lipids, specifically much higher HDL-C and much lower serum triglycerides.
This latest motivation comes from having attended the 3-day Nutritional Ketosis and Metabolic Therapeutics Conference in Tampa, FL, January 28-30. The sold-out meeting was presented by and intended for academics and clinicians (PhDs and MDs), and included many icons and luminaries in the field. As one of very few lay people attending, it was both eye opening and inspirational and a privilege to be present in this rarefied atmosphere.
My biggest takeaway was the very strong association shown in several presentations between the metabolic diseases whose incipient cause is insulin resistance at the cellular level both in the body and the brain, i.e. Type 2 Diabetes, and Alzheimer’s Disease (AD), the latter characterized by insulin resistance and glucose disregulation in specific regions of the brain. This similarity is explored in depth (for the serious reader) here in this 2008 peer- reviewed article (cited 68 times in PubMed), “Alzheimer’s Disease is Type 3 Diabetes – Evidence Reviewed,” by Suzanne M. de la Monte, M.D. I found this link on the website of Dr. Mary Newport, a conference presenter.
For the layman, Mark Bittman, former food writer at The New York Times, in 2012 wrote this opinion piece, “Is Alzheimer’s Type 3 Diabetes?” He must have seen Suzanne de la Monte on The Oz Show, where she appeared and then wrote this “fantastic and detailed summary” (Bittman), “Alzheimer’s: Diabetes of the Brain?” The best précis of the de la Monte piece, however, was in Bittman’s NYT piece. Here are selected excerpts:
“Let’s connect the dots: We know that the American diet is a fast track not only to obesity but to Type 2 diabetes and other preventable, non-communicable diseases, which now account for more deaths worldwide than all other causes combined. We also already know that people with diabetes are at least twice as likely to get Alzheimer’s, and that obesity alone increases the risk of impaired brain function. What’s new is the thought that while diabetes doesn’t ‘cause’ Alzheimer’s, they have the same root: an over consumption of those foods that mess with insulin’s many roles.”
Bittman, never one of my favorite food writers, especially after writing “VB6, Vegan before 6:00,” concluded,
“The link between diet and dementia negates our notion of Alzheimer’s as a condition that befalls us by chance. Adopting a sane diet, a diet contrary to the standard American diet (which I like to refer to as SAD), would appear to give you a far better shot at avoiding diabetes in all of its forms, along with its dreaded complications” [my emphasis on 'all'].
So far these points only make an argument for what I am already doing personally and cajoling my readers to do. However, the evidence presented at this conference, and in follow-up reading, has persuaded me to introduce ketones to my body every day as a prophylactic and/or therapeutic practice. Why? To avoid damage to the brain that evidence suggests occurs long before mild cognitive impairment (MCI) begins or is detectable. What is the rationale for this reliance on the daily availability of ketones?
“Ketone bodies are an alternative fuel for brain cells when glucose availability is insufficient,” Richard L. Veech says in this academic article in the Neurobiology of Aging: “A ketone ester diet exhibits anxiolytic and cognition-sparing properties, and lessens amyloid and tau pathologies in a mouse model of Alzheimer’s disease.” Dr. Veech is one of my (and Dr. Newport’s) favorite researchers. I quoted him in #322 and in four other blog posts going back 5 years. His 2013 piece above has already been cited in PubMed 30 times. Dr. Leech concludes:
“The present findings show that long-term feeding of ketone esters not only improved behavioral cognitive function but also decreased Aβ and pTau pathologic changes. The increase in blood ketone bodies, by either a ketogenic diet or by feeding a ketone ester, would be expected to alleviate the impaired brain glucose metabolism that precedes the onset of AD. Ketone bodies can bypass the block in glycolysis resulting from impairment of insulin function (Kashiwaya et al., 1997). Our preclinical findings suggest that a ketone ester-containing diet has the potential to retard the disease process and improve cognitive function of patients with AD.”
Thus, absent strict, daily adherence to a ketogenic diet, which is an onerous task, my “insurance” to assure the prophylactic and/or therapeutic benefit of ketone bodies on my brain metabolism is to supplement with ketones.

176 comments:

  1. Only skimmed the article (have read all of it from original sources). Great content, but: Make Sure that you are drinking Lots of water, to flush the ketones out of your kidneys!

    ReplyDelete
    Replies
    1. I don't understand. The liver makes the ketones by catabolizing triglycerides. The FFAs and the ketone bodies are then oxidized for energy. What is left to be flushed by the kidneys?

      Delete
  2. I get new energy because of all given information very excellent and real words to implemented for you. Thank you so much shared that valuable information.

    SEO Training in Chennai

    ReplyDelete
  3. Pretty article! I found some useful information in your blog, it was awesome to read, thanks for sharing this great content to my vision, keep sharing.
    Regards,'

    Best PMP Training in Chennai | SAP Training in Chennai

    ReplyDelete
    Replies
    1. Thank you, Fathima. I have a small following in Chennai (all of whom, like yourself, have their own websites to promote). I hope you will continue to read my column, and share it with others in Chennai.

      Delete
  4. Nice article by Dan brown.Now a days most of the population are suffering from obesity and there are many companies who are working on it and making a lot of medicines for fat lose among them Raspberry ketone is one of them but it is safe as compare to other.

    ReplyDelete
  5. You truly did more than visitors’ expectations. Thank you for rendering these helpful, trusted, edifying and also cool thoughts on the topic.
    MCA Project Center in Chennai | MCA Project Center in Velachery

    ReplyDelete
    Replies
    1. Thanks, Mary Adlena. It appears that I have a loyal group of followers in Chennai!

      Delete
  6. Awesome Blog, you have provided the right information that will be beneficial to us. Thanks for sharing your valuable Ideas to our vision. Robotics Project Center in Chennai | Best Robotics Projects in Chennai | IEEE Robotics Project Center in Chennai | No.1 Robotics Project Center in Velachery

    ReplyDelete
  7. Truly enjoying the design and layout of your blog. It’s a very easy on the eyes which makes it much more enjoyable for me to come here and visit more often. Did you hire out a developer to create your theme? Great work! Perfect Graphics Designing Training Institute in Chennai | Best CorelDraw Training Institute in Velachery

    ReplyDelete
    Replies
    1. Thanks, Grace. The Blogger platform provided all the graphics. I simply made choices from among the options offered.

      Delete
  8. You have done a great job, really the concept of Nutrition debate was superb, its very interesting and easy to understand also.. Keep updating such a nice blog..
    Automation Anywhere Training in Chennai | RPA Training Institute in Chennai | UI Path Training Institute in Chennai | Blue Prism Training Institute in Chennai

    ReplyDelete
    Replies
    1. Thanks, Adlina. That is my goal. I'm glad to have so many readers in Chennai.

      Delete
  9. Keep up the fantastic piece of work, I read few articles on this site and I think that your web site is very interesting and contains bands of excellent information. Excellent Photoshop Training Institute in Chennai | Best Multimedia Training Institute in Velachery

    ReplyDelete
    Replies
    1. Rupesh. Don't stop with a few. I have now published 425 columns, so you have more reading to do.

      Delete
  10. The best thing is that your blog really informative thanks for your great information!
    Image Processing Project Center in Chennai | Image Processing Project Center in Velachery

    ReplyDelete
  11. There was very wonderful information and that's great one. I really appreciate the kind words, thanks for sharing that valuable information.. Multimedia Technical Boot Camp in Chennai | Best Vacation Class in Guindy

    ReplyDelete
  12. Extremely Nice Blog I like the way you clarified these things.
    http://www.rippleslearning.com/train-the-trainer-courses-chennai/

    ReplyDelete
  13. I have read your blog its very attractive and impressive.I like it your blog...Java Project Center in Chennai | Java Project Center in Velachery

    ReplyDelete
  14. Really very great information to be provided and the All points discussed were worth reading and i’ll surely work with them all one by one..Embedded Project Center in Chennai | Embedded Project Center in Velachery

    ReplyDelete
  15. Really very great information to be provided and the All points discussed were worth reading..VLSI Project Center in Chennai | VLSI Project Center in Velachery

    ReplyDelete
  16. Given information was very excellent & Great tips, and awesome way to get exert tips from everyone..Java Project Center in Chennai | Java Project Center in Velachery

    ReplyDelete
  17. Thanks for this grateful information. all this information is very important to all the users and can be used good at all this process.
    Power System Project Center in Chennai | Power System Projects in Velachery

    ReplyDelete
  18. Really very great information to be provided and the All points discussed were worth reading..Embedded Project Center in Chennai | Embedded Project Center in Velachery

    ReplyDelete
  19. Thank you for this info, this is something I’ve been seeking for quite a bit..Embedded Project Center in Chennai | Embedded Project Center in Velachery


    ReplyDelete
  20. Really your post was very informative. Today's internet era learn selenium Training will helps you to reach your goal. InDesign Certification Training in Chennai | No.1 InDesign Course in Saidapet

    ReplyDelete
  21. Really very great information to be provided and the All points discussed..DotNet Project Center in Chennai | Dot Net Project Center in Velachery

    ReplyDelete
  22. I have read your blog its very attractive and impressive.I like it your blog..MatLab Project Center in Chennai | MatLab Projects Center in Velachery

    ReplyDelete
  23. Very useful post! The information that you have shared with us through post is very unique..Embedded Project Center in Chennai | Embedded Project Center in Velachery

    ReplyDelete
  24. Nice post. Great information and really very much useful. Thanks for sharing and keep updating.
    Redhat Linux Certification Exam Center in Chennai|Redhat Linux Certification Exam Center in Velachery

    ReplyDelete
  25. Great and useful information you are shared,thanks for sharing this helpful post here..
    Mobile Computing Projects in Chennai | Mobile Computing Projects in Velachery

    ReplyDelete
  26. Really great post. Thank you for sharing this knowledge. Excellently written article..<Java Project Center in Chennai | Java Project Center in Velachery

    ReplyDelete
  27. Very useful post..Thank you for sharing such a wonderful information.VLSI Project Center in Chennai | VLSI Project Center in Velachery

    ReplyDelete
  28. I have read your blog its very attractive and impressive.I like it your blog..DotNet Project Center in Chennai | DotNet Project Center in Velachery

    ReplyDelete
  29. I am so happy to read such a informative blog..Thank you for sharing..VLSI Project Center in Chennai | VLSI Project Center in Velachery

    ReplyDelete
  30. I have read your blog its very attractive and impressive.I like it your blog..Embedded Project Center in Chennai | Embedded Project Center in Velachery

    ReplyDelete
  31. Great post. Wonderful information and really very much useful. Thanks for sharing and keep updating. DotNet Project Center in Chennai | DotNet Project Center in Velachery

    ReplyDelete
  32. I am so happy to read such a informative blog..Thank you for sharing..Java Project Center in Chennai | Java Project Center in Velachery

    ReplyDelete
  33. I read your articles very excellent ,In the site was very excellent,i think this is very best one compare others and then the more information to get after read this post.
    VMware Exam Centers in Chennai | VMware Exam Centers in Velachery

    ReplyDelete
  34. Very good and informative article. Thanks for sharing such nice article, keep on updating such good articles.
    No.1 MCSE and MCSA Certificate Exam Centre in Chennai |No.1 MCSE and MCSA Certificate Exam Centre in Chennai.

    ReplyDelete
  35. Nice blog. I feel really happy to have seen your webpage and look forward to so many more entertaining times reading here. Thanks once more for all the details.
    Best Python Certificate EXAM Center in Chennai| Best Python Certificate EXAM Center in Velachery

    ReplyDelete
  36. Thank you for creating this awesome guide! It’s very interesting with lots of actionable tips.DotNet Project Center in Chennai |DotNet Project Center in Velachery

    ReplyDelete
  37. Really very great information to be provided and the All points discussed were worth reading and i’ll surely work with them all one by one.
    Multimedia Course in Chennai | Multimedia Course in Velachery

    ReplyDelete
  38. This comment has been removed by a blog administrator.

    ReplyDelete
  39. This comment has been removed by a blog administrator.

    ReplyDelete
  40. This comment has been removed by a blog administrator.

    ReplyDelete
  41. This comment has been removed by a blog administrator.

    ReplyDelete
  42. This comment has been removed by a blog administrator.

    ReplyDelete

  43. Awesome Blog, you have provided the right information that will be beneficial to us. Best summer course for school students in chennai training in kanchipuram

    ReplyDelete
  44. Nice blog. Thank you for sharing. The information you shared is very effective for learners I have got some important suggestions from it

    Best C and C++ programming training academy in Kanchipuram

    ReplyDelete
  45. Nice blog, really I feel happy to see this useful blog… Thanks for sharing this valuable information to our vision.

    Best Graphics Designing Training Academy in Kanchipuram

    ReplyDelete
  46. very nice blogs!!! i have to learning for lot of information for this sites...Sharing for wonderful information. Thanks for sharing this valuable information to our vision. You have posted a trust worthy blog keep sharing

    Best AWS Training Academy in Kanchipuram

    ReplyDelete
  47. Awesome post. Really you are shared very informative concept... Thank you for sharing. Keep on updating...

    Best Graphics Designing Training Academy in Kanchipuram

    ReplyDelete
  48. Good Post! Thank you so much for sharing this pretty post, it was so good to read and useful to improve my knowledge as updated one, keep blogging…

    Best Web Designing Training Academy in Kanchipuram

    ReplyDelete
  49. I simply wanted to write down a quick word to say thanks to you for those wonderful tips and hints you are showing on this site.
    Azure Training in Chennai

    ReplyDelete
  50. Thanks for this grateful information. all this information is very important to all the users and can be used good at all this process.


    Best Web Designing Training Academy in Kanchipuram

    ReplyDelete
  51. Excellent post!!!. The strategy you have posted on this technology helped me to get into the next level and had lot of information in it.
    Best web Designing Training Training Institute in Kanchipuram

    ReplyDelete
  52. Thanks again, and again, and again, deepti! I hope you re-read them each time you post a "comment"!

    ReplyDelete
  53. I have read your blog. Good and more information useful for me, Thanks for sharing this information keep it up....
    Dot Net Project Center in Chennai | Dot Net Project Center in Velachery | Dot Net Projects in OMR

    ReplyDelete
  54. This comment has been removed by a blog administrator.

    ReplyDelete
  55. Very interesting blog which helps me to get the in depth knowledge about the technology, Thanks for sharing such a nice blog...
    IOT Project Center in Chennai | IOT Project Center in Velachery | IOT Projects for BE in Pallikaranai | IOT Projects for ME in Taramani

    ReplyDelete
  56. Really Very happy to see this blog. thanks for sharing such a amazing blog...
    Final Year Project Center in Chennai | Final Year Projects in Velachery

    ReplyDelete
  57. This comment has been removed by a blog administrator.

    ReplyDelete
  58. Srihariparu, this is the 12th time you have commented on this one post (#325). Have you read anything else that I have posted? I have posted 860 different essays. Just think of all the opportunities to advertise that you have missed!

    ReplyDelete
  59. Awesome Blog with informative concept. Really I feel happy to see this useful blog, Thanks for sharing such a nice blog.
    Java Project Center in Chennai | Java Projects Center in Velachery | Java Projects in Perungudi

    ReplyDelete
  60. Very interesting, good job and thanks for sharing such blog. It is very interesting to read. Its pretty good and well noted.
    Cloud Computing Project Center in Chennai | Cloud Computing Projects in Velachery

    ReplyDelete
  61. srihariparu, You are such a faithful reader! You say you read this post just 3 days ago! and again 4 days before that, and again 4 days before that. Do you perhaps have early onset dementia?

    ReplyDelete
  62. Thanks again, srihariparu, for your twice-weekly endorsement.

    ReplyDelete
  63. Thanks, w3web. Nice to have another reader in Kalkata.

    ReplyDelete
  64. I read this article. I think You put a lot of effort to create this article. I appreciate your work.
    Embedded System Training Institute in Chennai | Embedded Training Center in Velachery | Embedded Training in Guindy

    ReplyDelete
  65. Replies
    1. I hope my blog is productive for you, deepti.

      Delete
  66. This comment has been removed by a blog administrator.

    ReplyDelete
  67. It is very awesome and wonderful to visit your site.Thanks for sharing this information,this is helpful to me a lot...
    Java Training Institute in Chennai | java Training Center in Velachery | Java Training in Velachery | Online Training Institute in Velachery

    ReplyDelete
  68. Thanks, srihariparu. You must have this post memorized by now.
    Dan Brown

    ReplyDelete
  69. Your Post is really wonderful and amazing content.Thanks for sharing such a useful blog and really good...
    Java Training Institute in Chennai | Java Training Center in Velachery | Online Training Institute in Velachery

    ReplyDelete
  70. Brilliant article. The information I have been searching precisely. It helped me a lot, thanks. Keep coming with more such informative article.
    C and C++ Training Institute in Chennai | C and C++ Training Center in Velachery | C & C++ Training in Velachery | Online Training in Velachery

    ReplyDelete
  71. Really excellent blog.It is very useful for us. Thaks for for such amazing blog. Keep sharing such excellent blog.
    PMP Certification Center in Chennai | PMP Certification Online Training | PMP Certification Offline Training

    ReplyDelete
  72. Very informative blog.Thanks for sharing such a excellent blog.It is very useful for us.keep sharing

    such amazing blogs.
    SELENIUM Training

    institute in chennai
    | SELENIUM Online Training institute in chennai | SELENIUM Offline

    Training institute in chennai

    ReplyDelete
  73. Really very nice blog.It is very informative and useful for everyone.Thanks for sharing a wonderful blog.
    AWS Training Institute in Chennai | AWS Online Training Institute in Chennai | AWS Offline Training Institute in Chennai

    ReplyDelete
  74. “Great share!” Each and every tips of your post are more informative and it was awesome to read.
    Thank you for such a great post…..

    ReplyDelete
  75. Really very nice article!… Its shows amazing information with unique content. Thanks a lot for sharing such a wonderful article,
    JAVA Training Institute in Velachery | JAVA Training Institute in Chennai

    ReplyDelete
  76. Your Blog is really an amazing content to read, its very useful for everyone. thanks for sharing such an wonderful post..
    PMP Exam Center in Chennai | PMP Certification in Velachery | PMP Exams in Velachery | Online Certification in Chennai

    ReplyDelete
  77. Good information and really its very much useful Blog . Thanks for sharing and keep updating like this …….
    GRE Exams in Chennai|
    GRE Exams in Velachery|
    GRE Exams in Tharamani|
    GRE Exams in Perungudi|
    GRE Exams in Thambaram

    ReplyDelete
  78. Good information and really its very much useful Blog . Thanks for sharing and keep updating like this …….
    IELTS Exams in Chennai|
    IELTS Exams in Velachery|
    IELTS Exams in Tharamani|
    IELTS Exams in Perungudi|
    IELTS Exams in Thambaram

    ReplyDelete
  79. Nice post.. Its really an amazing with informative information and useful for everyone. Thanks for sharing your wonderful article..

    AWS Certification in Chennai | AWS Exam Center in Chennai | AWS Exams in Velacheri | AWS Online Exams in Velachery | Online Certification in Chennai

    ReplyDelete
  80. Really it was an awesome article...very interesting to read. You have provided an nice article....Thanks for sharing..
    MBA Project Center in Chennai | MBA Projects in Velachery

    ReplyDelete
  81. Really nice blog.. Thanks for posting this interesting article with us
    AWS Certification in Chennai | AWS Exam Center in Velachery

    ReplyDelete
  82. Alltechzsolutions provides 100% real-time, practical and placement focused CCNA training in Chennai. Our CCNA course concentrates from basic level training to advanced level training. Our CCNA® training in completely focused to get placement in MNC in Chennai and certification on CCNA after completion of our course. Our team of CCNA trainers are CCNA certified professionals with more real-time experience in live projects. Our CCNA® Course syllabus is enough for anyone who wants to get CCNA certification which meets industry expectations. In our course plan, you will learn Networking concepts,OSI – Model,TCP/IP Model & Ipv4 Addressing, with practical exercises and live examples.Alltechzsolutions offer both off line and online courses.

    ReplyDelete