If you have Metabolic Syndrome
(see Retrospective #9 for the indications) there is a greater risk that you
will develop certain types of cancer, according to a systematic review and
meta-analysis reported November 2012 in Medscape. The retrospective study was
performed by a group of physician-researchers and was published in the American
Diabetes Association’s journal, Diabetes Care. The study reports an association with cancer risk, not a causal relationship.
If you didn’t go back to# 9,
Metabolic Syndrome is defined by a cluster of risk factors: 1) obesity,
particularly central obesity, 2) dysglycemia (i.e. Pre-diabetes or Type 2), 3)
elevated blood pressure, 4) and dyslipidemia, specifically high triglycerides
and low HDL. Between 35% and 40% of the adult population of the U. S. today has
Metabolic Syndrome.
In 1986, when I was first diagnosed
as a Type 2 diabetic, I had every one of risk factors for Metabolic Syndrome,
but no one told me I had it, or Syndrome X as it was then called. In fact, to
this day no one has told me. Why is that, I wonder? Especially since the
implications go far beyond cancer risk. The risks of virtually all the
so-called Diseases of Civilization (heart disease, stroke, Alzheimer’s, etc.)
are associated with a diagnosis of Metabolic Syndrome. Do you have Metabolic
Syndrome? If you don’t know or aren’t sure, you really should go back and take
a look at Retrospective #9 now.
From the results of the report
in Diabetes Care (pg.1): “We analyzed
116 datasets from 43 articles, including 38,940 cases of cancer. In cohort
studies in men, the presence of Metabolic Syndrome was associated with liver,
colorectal and bladder cancer. In cohort studies in women, the presence of
Metabolic Syndrome was associated with endometrial, pancreatic, breast
postmenopausal, rectal and colorectal cancers. Associations with Metabolic
Syndrome were stronger in women than in men for pancreatic and rectal cancers.
Associations were different between ethnic groups: we recorded stronger
associations in Asia populations for liver cancer, in European populations for
colorectal cancer in women, and in U. S. populations (whites) for prostate
cancer.” “Metabolic Syndrome is associated with increased risk of common
cancers; for some cancers the risk differs between sexes, populations and
definitions of Metabolic Syndrome.”
Additional detailed conclusions
from the full text of the report (page 28) drive home the findings: “Our
results from meta-analyses of prospective cohort studies indicate that Metabolic
Syndrome is consistently associated with an increased risk of several cancers
in adults. However, many of the reported associations are small (relative risk
between 1.1 and 1.6) and might differ between sexes for some sites and also
across populations. In particular, the associations were stronger in women for
some cancers (pancreas and rectal), and the magnitude of the association was
highest for sex specific cancers (endometrial and breast postmenopausal).
Moreover, from analyses in which sufficient datasets existed, the association
was stronger for colorectal cancer in European populations (relative risk
1.64).”
And this hit: “Given the
widespread diffusion of Metabolic Syndrome and the increased cancer mortality
associated with Metabolic Syndrome, the findings of the present meta-analysis
may have clinical significance. At least for some common cancer sites
(colorectal cancer in both sexes, liver cancer in men, and pancreas cancer in
women), we are confident that the results are real, as the grading for study
quality was moderate to high and overall risk of bias was low” ( pg. 28).
Finally this blow (pg. 28):
“Findings from this meta-analysis, which includes many recently published
studies, suggest that Metabolic Syndrome is associated with increased risk of
common cancers. The excess risk of cancer conferred by Metabolic Syndrome is
low to moderate and in part explained by accompanying obesity and
hyperglycemia. Neverthe-less, the increasing prevalence of Metabolic Syndrome
worldwide and the high incidence of some malignancies, particu-larly colorectal
and breast cancers, imply that every year many cases of cancer are attributable to Metabolic
Syndrome” (emphasis mine). Remember, this is a retrospective, meta-analysis –
not a prospective double-blind clinical trial, but to use the words
“attributable to” is, to be sure, pretty strong language. It certainly should
give one pause for thought.
For example, are you thinking,
“What can I do about it?” Well, you could change your diet. You could lose
weight easily and keep it off permanently by eating a Very Low Carb ketogenic
diet. With this diet your blood glucose will normalize, and with weight loss
your blood pressure will come down. And this diet will raise your HDL and lower
your triglycerides. These are the
indications for Metabolic Syndrome, and they can all go away. You will be free
of Metabolic Syndrome. Ipso facto!
You wrote this post Cancer Treatment Center For America very carefully. The amount of information is stunning and also a gainful article for us. Keep sharing this kind of articles, Thank you.
ReplyDelete